Pharmacokinetics-Pharmacodynamics of a Novel β-Lactamase Inhibitor, CB-618, in Combination with Meropenem in an In Vitro Infection Model

The usefulness of β-lactam antimicrobial agents is threatened as never before by β-lactamase-producing bacteria. For this reason, there has been renewed interest in the development of broad-spectrum β-lactamase inhibitors. Herein we describe the results of dose fractionation and dose-ranging studies...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: VanScoy, Brian D., Trang, Michael, McCauley, Jennifer, Conde, Haley, Bhavnani, Sujata M., Friedrich, Lawrence V., Alexander, Dylan C., Ambrose, Paul G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914694/
https://ncbi.nlm.nih.gov/pubmed/27001820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02943-15
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