Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense

This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense. The proliferation of T. congolense was completely inhibited by adding <1 μM MPA and its derivatives. In addition, the IMP dehydrogenase in T. congolense was molecularl...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Suganuma, Keisuke, Sarwono, Albertus Eka Yudistira, Mitsuhashi, Shinya, Jąkalski, Marcin, Okada, Tadashi, Nthatisi, Molefe, Yamagishi, Junya, Ubukata, Makoto, Inoue, Noboru
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914658/
https://ncbi.nlm.nih.gov/pubmed/27139487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02816-15
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