Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening

Inosine 5′-monophosphate dehydrogenase (IMPDH) is an essential enzyme for the production of guanine nucleotides. Disruption of IMPDH activity has been explored as a therapeutic strategy for numerous purposes, such as for anticancer, immunosuppression, antiviral, and antimicrobial therapy. In the pre...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Sarwono, Albertus Eka Yudistira, Mitsuhashi, Shinya, Kabir, Mohammad Hazzaz Bin, Shigetomi, Kengo, Okada, Tadashi, Ohsaka, Fumina, Otsuguro, Satoko, Maenaka, Katsumi, Igarashi, Makoto, Kato, Kentaro, Ubukata, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249553/
https://ncbi.nlm.nih.gov/pubmed/30451014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1540474
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