Paradoxical Effect of Polymyxin B: High Drug Exposure Amplifies Resistance in Acinetobacter baumannii

Administering polymyxin antibiotics in a traditional fashion may be ineffective against Gram-negative ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens. Here, we explored increasing the dos...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Tsuji, Brian T., Landersdorfer, Cornelia B., Lenhard, Justin R., Cheah, Soon-Ee, Thamlikitkul, Visanu, Rao, Gauri G., Holden, Patricia N., Forrest, Alan, Bulitta, Jürgen B., Nation, Roger L., Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2016
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914656/
https://ncbi.nlm.nih.gov/pubmed/27067330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02831-15
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