載入...
High Systemic Exposure of Pyrazinoic Acid Has Limited Antituberculosis Activity in Murine and Rabbit Models of Tuberculosis
Pyrazinamide (PZA) is a prodrug requiring conversion to pyrazinoic acid (POA) by an amidase encoded by pncA for in vitro activity. Mutation of pncA is the most common cause of PZA resistance in clinical isolates. To determine whether the systemic delivery of POA or host-mediated conversion of PZA to...
Na minha lista:
| 發表在: | Antimicrob Agents Chemother |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2016
|
| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4914615/ https://ncbi.nlm.nih.gov/pubmed/27139472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03085-15 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|