High Systemic Exposure of Pyrazinoic Acid Has Limited Antituberculosis Activity in Murine and Rabbit Models of Tuberculosis

Pyrazinamide (PZA) is a prodrug requiring conversion to pyrazinoic acid (POA) by an amidase encoded by pncA for in vitro activity. Mutation of pncA is the most common cause of PZA resistance in clinical isolates. To determine whether the systemic delivery of POA or host-mediated conversion of PZA to...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Antimicrob Agents Chemother
मुख्य लेखकों: Lanoix, Jean-Philippe, Tasneen, Rokeya, O'Brien, Paul, Sarathy, Jansy, Safi, Hassan, Pinn, Michael, Alland, David, Dartois, Véronique, Nuermberger, Eric
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 2016
विषय:
Experimental Therapeutics
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914615/
https://ncbi.nlm.nih.gov/pubmed/27139472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03085-15
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