Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques

Most simian–human immunodeficiency viruses (SHIVs) bearing envelope (Env) glycoproteins from primary HIV-1 strains fail to infect rhesus macaques (RMs). We hypothesized that inefficient Env binding to rhesus CD4 (rhCD4) limits virus entry and replication and could be enhanced by substituting natural...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Li, Hui, Wang, Shuyi, Kong, Rui, Ding, Wenge, Lee, Fang-Hua, Parker, Zahra, Kim, Eunlim, Learn, Gerald H., Hahn, Paul, Policicchio, Ben, Brocca-Cofano, Egidio, Deleage, Claire, Hao, Xingpei, Chuang, Gwo-Yu, Gorman, Jason, Gardner, Matthew, Lewis, Mark G., Hatziioannou, Theodora, Santra, Sampa, Apetrei, Cristian, Pandrea, Ivona, Alam, S. Munir, Liao, Hua-Xin, Shen, Xiaoying, Tomaras, Georgia D., Farzan, Michael, Chertova, Elena, Keele, Brandon F., Estes, Jacob D., Lifson, Jeffrey D., Doms, Robert W., Montefiori, David C., Haynes, Barton F., Sodroski, Joseph G., Kwong, Peter D., Hahn, Beatrice H., Shaw, George M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914158/
https://ncbi.nlm.nih.gov/pubmed/27247400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606636113
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados