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T Regulatory Cell Depletion Reactivates Latent SIV in Controller Macaques while Boosting SIV-specific T Lymphocytes
T regulatory cells (Tregs) are critical in shaping the latent HIV/SIV reservoir, as they are preferentially infected, reverse CD4(+) T cell activation status and suppress CTL responses. To reactivate latent virus and boost cell-mediated immune responses, we performed in vivo Treg depletion with Onta...
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| Gepubliceerd in: | J Immunol |
|---|---|
| Hoofdauteurs: | , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5441309/ https://ncbi.nlm.nih.gov/pubmed/27837106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601539 |
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