T Regulatory Cell Depletion Reactivates Latent SIV in Controller Macaques while Boosting SIV-specific T Lymphocytes

T regulatory cells (Tregs) are critical in shaping the latent HIV/SIV reservoir, as they are preferentially infected, reverse CD4(+) T cell activation status and suppress CTL responses. To reactivate latent virus and boost cell-mediated immune responses, we performed in vivo Treg depletion with Onta...

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Veröffentlicht in:J Immunol
Hauptverfasser: He, Tianyu, Brocca-Cofano, Egidio, Policicchio, Benjamin B., Sivanandham, Ranjit, Gautam, Rajeev, Raehtz, Kevin D., Xu, Cuiling, Pandrea, Ivona, Apetrei, Cristian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441309/
https://ncbi.nlm.nih.gov/pubmed/27837106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601539
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