Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques

Most simian–human immunodeficiency viruses (SHIVs) bearing envelope (Env) glycoproteins from primary HIV-1 strains fail to infect rhesus macaques (RMs). We hypothesized that inefficient Env binding to rhesus CD4 (rhCD4) limits virus entry and replication and could be enhanced by substituting natural...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Li, Hui, Wang, Shuyi, Kong, Rui, Ding, Wenge, Lee, Fang-Hua, Parker, Zahra, Kim, Eunlim, Learn, Gerald H., Hahn, Paul, Policicchio, Ben, Brocca-Cofano, Egidio, Deleage, Claire, Hao, Xingpei, Chuang, Gwo-Yu, Gorman, Jason, Gardner, Matthew, Lewis, Mark G., Hatziioannou, Theodora, Santra, Sampa, Apetrei, Cristian, Pandrea, Ivona, Alam, S. Munir, Liao, Hua-Xin, Shen, Xiaoying, Tomaras, Georgia D., Farzan, Michael, Chertova, Elena, Keele, Brandon F., Estes, Jacob D., Lifson, Jeffrey D., Doms, Robert W., Montefiori, David C., Haynes, Barton F., Sodroski, Joseph G., Kwong, Peter D., Hahn, Beatrice H., Shaw, George M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914158/
https://ncbi.nlm.nih.gov/pubmed/27247400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606636113
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