p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia

The retinoblastoma gene product (pRb) controls proliferation and differentiation processes in stratified epithelia. Importantly, an in contrast to other tissues, Rb deficiency does not lead to spontaneous skin tumor formation. As the cyclin dependent kinase inhibitor p21 regulates proliferation and...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Saiz-Ladera, Cristina, Lara, María Fernanda, Garín, Marina, Ruiz, Sergio, Santos, Mirentxu, Lorz, Corina, García-Escudero, Ramón, Martínez-Fernández, Mónica, Bravo, Ana, Fernández-Capetillo, Oscar, Segrelles, Carmen, Paramio, Jesús M
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4913869/
https://ncbi.nlm.nih.gov/pubmed/24121270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.417
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