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Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension
Recent studies have demonstrated that the expression of sphingosine kinase 1, the enzyme that catalyses formation of the bioactive lipid, sphingosine 1-phosphate, is increased in lungs from patients with pulmonary arterial hypertension. In addition, Sk1(−/−) mice are protected from hypoxic-induced p...
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| Publicado en: | Cell Signal |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Elsevier Science Ltd
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4913619/ https://ncbi.nlm.nih.gov/pubmed/27063355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2016.03.014 |
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