Llwytho...

Effect of sphingosine kinase modulators on interleukin‐1β release, sphingosine 1‐phosphate receptor 1 expression and experimental autoimmune encephalomyelitis

BACKGROUND AND PURPOSE: The sphingosine analogue, FTY720 (Gilenya(R)), alleviates clinical disease progression in multiple sclerosis. Here, we variously assessed the effects of an azide analogue of (S)‐FTY720 vinylphosphonate (compound 5; a sphingosine kinase 1 activator), (R)‐FTY720 methyl ether (R...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Pharmacol
Prif Awduron: Barbour, Mark, McNaughton, Melissa, Boomkamp, Stephanie D, MacRitchie, Neil, Jiang, Hui‐Rong, Pyne, Nigel J, Pyne, Susan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192795/
https://ncbi.nlm.nih.gov/pubmed/27864936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13670
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