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Effect of sphingosine kinase modulators on interleukin‐1β release, sphingosine 1‐phosphate receptor 1 expression and experimental autoimmune encephalomyelitis
BACKGROUND AND PURPOSE: The sphingosine analogue, FTY720 (Gilenya(R)), alleviates clinical disease progression in multiple sclerosis. Here, we variously assessed the effects of an azide analogue of (S)‐FTY720 vinylphosphonate (compound 5; a sphingosine kinase 1 activator), (R)‐FTY720 methyl ether (R...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5192795/ https://ncbi.nlm.nih.gov/pubmed/27864936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13670 |
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