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Inhibiting Smad2/3 Signaling In Pluripotent Mouse Embryonic Stem Cells Enhances Endoderm Formation By Increasing Transcriptional Priming Of Lineage-Specifying Target Genes

BACKGROUND: Pluripotent embryonic stem cells (ESCs) offer great potential for regenerative medicine. However, efficient in vitro generation of specific desired cell types is still a challenge. We previously established that Smad2/3 signaling, essential for endoderm formation, regulates target gene e...

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Bibliografische gegevens
Gepubliceerd in:Dev Dyn
Hoofdauteurs: Dahle, Øyvind, Kuehn, Michael R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912923/
https://ncbi.nlm.nih.gov/pubmed/27012147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.24407
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