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Inhibiting Smad2/3 Signaling In Pluripotent Mouse Embryonic Stem Cells Enhances Endoderm Formation By Increasing Transcriptional Priming Of Lineage-Specifying Target Genes
BACKGROUND: Pluripotent embryonic stem cells (ESCs) offer great potential for regenerative medicine. However, efficient in vitro generation of specific desired cell types is still a challenge. We previously established that Smad2/3 signaling, essential for endoderm formation, regulates target gene e...
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Gepubliceerd in: | Dev Dyn |
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Hoofdauteurs: | , |
Formaat: | Artigo |
Taal: | Inglês |
Gepubliceerd in: |
2016
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Onderwerpen: | |
Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4912923/ https://ncbi.nlm.nih.gov/pubmed/27012147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.24407 |
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