Polycomb enables primitive endoderm lineage priming in embryonic stem cells

Mouse embryonic stem cells (ESCs), like the blastocyst from which they are derived, contain precursors of the epiblast (Epi) and primitive endoderm (PrEn) lineages. While transient in vivo, these precursor populations readily interconvert in vitro. We show that altered transcription is the driver of...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Illingworth, Robert S, Hölzenspies, Jurriaan J, Roske, Fabian V, Bickmore, Wendy A, Brickman, Joshua M
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2016
Teme:
Developmental Biology and Stem Cells
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056788/
https://ncbi.nlm.nih.gov/pubmed/27723457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14926
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