Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage

We report here an approach to redirecting somatic cell fate under chemically defined conditions without transcription factors. We start by converting mouse embryonic fibroblasts to epithelial-like cells with chemicals and growth factors. Subsequent cell fate mapping reveals a robust induction of SOX...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Cao, Shangtao, Yu, Shengyong, Chen, Yan, Wang, Xiaoshan, Zhou, Chunhua, Liu, Yuting, Kuang, Junqi, Liu, He, Li, Dongwei, Ye, Jing, Qin, Yue, Chu, Shilong, Wu, Linlin, Guo, Lin, Li, Yinxiong, Shu, Xiaodong, Chen, Jiekai, Liu, Jing, Pei, Duanqing
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704493/
https://ncbi.nlm.nih.gov/pubmed/28935668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.812537
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