Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage

We report here an approach to redirecting somatic cell fate under chemically defined conditions without transcription factors. We start by converting mouse embryonic fibroblasts to epithelial-like cells with chemicals and growth factors. Subsequent cell fate mapping reveals a robust induction of SOX...

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Vydáno v:J Biol Chem
Hlavní autoři: Cao, Shangtao, Yu, Shengyong, Chen, Yan, Wang, Xiaoshan, Zhou, Chunhua, Liu, Yuting, Kuang, Junqi, Liu, He, Li, Dongwei, Ye, Jing, Qin, Yue, Chu, Shilong, Wu, Linlin, Guo, Lin, Li, Yinxiong, Shu, Xiaodong, Chen, Jiekai, Liu, Jing, Pei, Duanqing
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704493/
https://ncbi.nlm.nih.gov/pubmed/28935668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.812537
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