Circadian Amplitude Regulation via FBXW7-targeted REV-ERBα Degradation

Defects in circadian rhythm influence physiology and behavior with implications for the treatment of sleep disorders, metabolic disease and cancer. Although core regulatory components of clock rhythmicity have been defined, insight into the mechanisms underpinning amplitude is limited. We show here...

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Udgivet i:Cell
Main Authors: Zhao, Xuan, Hirota, Tsuyoshi, Han, Xuemei, Cho, Han, Chong, Ling-Wa, Lamia, Katja, Liu, Sihao, Atkins, Annette R., Banayo, Ester, Liddle, Christopher, Yu, Ruth T., Yates, John R., Kay, Steve A., Downes, Michael, Evans, Ronald M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912445/
https://ncbi.nlm.nih.gov/pubmed/27238018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.012
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