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A Computational Drug Repositioning Approach for Targeting Oncogenic Transcription Factors
Mutations in transcription factors (TFs) genes are frequently observed in tumors, often leading to aberrant transcriptional activity. Unfortunately, TFs are often considered undruggable due to the absence of targetable enzymatic activity. To address this problem, we developed CRAFTT, a Computational...
שמור ב:
| הוצא לאור ב: | Cell Rep |
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| Main Authors: | , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4912004/ https://ncbi.nlm.nih.gov/pubmed/27264179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.037 |
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