S1-DRIP-seq identifies high expression and polyA tracts as major contributors to R-loop formation

R loops form when transcripts hybridize to homologous DNA on chromosomes, yielding a DNA:RNA hybrid and a displaced DNA single strand. R loops impact the genome of many organisms, regulating chromosome stability, gene expression, and DNA repair. Understanding the parameters dictating R-loop formatio...

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Foilsithe in:Genes Dev
Main Authors: Wahba, Lamia, Costantino, Lorenzo, Tan, Frederick J., Zimmer, Anjali, Koshland, Douglas
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory Press 2016
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911931/
https://ncbi.nlm.nih.gov/pubmed/27298336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.280834.116
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