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Genome-wide map of R-loop induced damage reveals how a subset of R-loops contribute to genomic instability
DNA-RNA hybrids associated with R-loops promote DNA damage and genomic instability. The capacity of hybrids at different genomic sites to cause DNA damage was not known, and the mechanisms leading from hybrid to damage were poorly understood. Here, we adopt a new strategy to map and characterize the...
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| Publicat a: | Mol Cell |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6264797/ https://ncbi.nlm.nih.gov/pubmed/30078723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.06.037 |
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