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Genome-wide map of R-loop induced damage reveals how a subset of R-loops contribute to genomic instability

DNA-RNA hybrids associated with R-loops promote DNA damage and genomic instability. The capacity of hybrids at different genomic sites to cause DNA damage was not known, and the mechanisms leading from hybrid to damage were poorly understood. Here, we adopt a new strategy to map and characterize the...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Costantino, Lorenzo, Koshland, Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264797/
https://ncbi.nlm.nih.gov/pubmed/30078723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.06.037
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