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A two-way street: regulatory interplay between RNA polymerase and nascent RNA structure
The vectorial (5′-to-3′ at varying velocity) synthesis of RNA by cellular RNA polymerases creates a rugged kinetic landscape, demarcated by frequent, sometimes long-lived pauses. In addition to myriad gene-regulatory roles, these pauses temporally and spatially program the co-transcriptional, hierar...
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| Veröffentlicht in: | Trends Biochem Sci |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4911296/ https://ncbi.nlm.nih.gov/pubmed/26822487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2015.12.009 |
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