Understanding and Controlling Sialylation in a CHO Fc-Fusion Process

A Chinese hamster ovary (CHO) bioprocess, where the product is a sialylated Fc-fusion protein, was operated at pilot and manufacturing scale and significant variation of sialylation level was observed. In order to more tightly control glycosylation profiles, we sought to identify the cause of variab...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Lewis, Amanda M., Croughan, William D., Aranibar, Nelly, Lee, Alison G., Warrack, Bethanne, Abu-Absi, Nicholas R., Patel, Rutva, Drew, Barry, Borys, Michael C., Reily, Michael D., Li, Zheng Jian
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911072/
https://ncbi.nlm.nih.gov/pubmed/27310468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157111
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