Understanding and Controlling Sialylation in a CHO Fc-Fusion Process

A Chinese hamster ovary (CHO) bioprocess, where the product is a sialylated Fc-fusion protein, was operated at pilot and manufacturing scale and significant variation of sialylation level was observed. In order to more tightly control glycosylation profiles, we sought to identify the cause of variab...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lewis, Amanda M., Croughan, William D., Aranibar, Nelly, Lee, Alison G., Warrack, Bethanne, Abu-Absi, Nicholas R., Patel, Rutva, Drew, Barry, Borys, Michael C., Reily, Michael D., Li, Zheng Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911072/
https://ncbi.nlm.nih.gov/pubmed/27310468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157111
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