Orlistat and antisense-miRNA-loaded PLGA-PEG nanoparticles for enhanced triple negative breast cancer therapy

BACKGROUND: This study explores the use of hydrophilic poly(ethylene glycol)-conjugated poly(lactic-co-glycolic acid) nanoparticles (PLGA-PEG-NPs) as delivery system to improve the antitumor effect of antiobesity drug orlistat for triple-negative breast cancer (TNBC) therapy by improving its bioavai...

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Bibliographic Details
Published in:Nanomedicine (Lond)
Main Authors: Bhargava-Shah, Aarohi, Foygel, Kira, Devulapally, Rammohan, Paulmurugan, Ramasamy
Format: Artigo
Language:Inglês
Published: Future Medicine Ltd 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910964/
https://ncbi.nlm.nih.gov/pubmed/26787319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.15.193
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