Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis

PDGF-BB/PDGFR-ββ signaling plays very crucial roles in the process of many diseases such as liver fibrosis. However, drug candidates with selective affinities for PDGF-B/PDGFR-β remain deficient. Here, we identified a natural cyclopeptide termed destruxin A5 that effectively inhibits PDGF-BB-induced...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Wang, Xingqi, Wu, Xuefeng, Zhang, Aihua, Wang, Shiyu, Hu, Chunhui, Chen, Wei, Shen, Yan, Tan, Renxiang, Sun, Yang, Xu, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909612/
https://ncbi.nlm.nih.gov/pubmed/27322468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.03.042
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