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Reversal of cytosolic one-carbon flux compensates for loss of mitochondrial folate pathway
One-carbon (1C) units for purine and thymidine synthesis can be generated from serine by cytosolic or mitochondrial folate metabolism. The mitochondrial 1C pathway is consistently overexpressed in cancer. Here we show that most but not all proliferating mammalian cell lines use the mitochondrial pat...
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| 發表在: | Cell Metab |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4909566/ https://ncbi.nlm.nih.gov/pubmed/27211901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.04.016 |
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