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Side-chain-to-tail cyclization of ribosomally derived peptides promoted by aryl and alkyl amino-functionalized unnatural amino acids

A strategy for the production of side-chain-to-tail cyclic peptides from ribosomally derived polypeptide precursors is reported. Two genetically encodable unnatural amino acids, bearing either an aryl or alkyl amino group, were investigated for their efficiency toward promoting the formation of medi...

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Detalhes bibliográficos
Publicado no:Org Biomol Chem
Main Authors: Frost, John R., Wu, Zhijie, Lam, Yick Chong, Owens, Andrew E., Fasan, Rudi
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909536/
https://ncbi.nlm.nih.gov/pubmed/27064594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob00192k
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