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Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Amino-Thiol Unnatural Amino Acids

A versatile method for orchestrating the formation of side-chain-to-tail cyclic peptides from ribosomally derived polypeptide precursors is reported. Upon ribosomal incorporation into intein-containing precursor proteins, designer unnatural amino acids bearing side-chain 1,3- or 1,2-aminothiol funct...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Frost, John R., Jacob, Nicholas T., Papa, Louis J., Owens, Andrew E., Fasan, Rudi
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546577/
https://ncbi.nlm.nih.gov/pubmed/25933125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00119
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