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Expanded toolbox for directing the biosynthesis of macrocyclic peptides in bacterial cells

The macrocyclization of recombinant polypeptides by means of genetically encodable non-canonical amino acids has recently provided an attractive strategy for the screening and discovery of macrocyclic peptide inhibitors of protein–protein interactions. Here, we report the development of an expanded...

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Publicado en:Chem Sci
Main Authors: Iannuzzelli, Jacob A., Fasan, Rudi
Formato: Artigo
Idioma:Inglês
Publicado: Royal Society of Chemistry 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7480269/
https://ncbi.nlm.nih.gov/pubmed/32953014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc01699c
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