Structure of the I-SceI nuclease complexed with its dsDNA target and three catalytic metal ions

Homing endonucleases are highly specific DNA-cleaving enzymes that recognize and cleave long stretches of DNA. The engineering of these enzymes provides instruments for genome modification in a wide range of fields, including gene targeting. The homing endonuclease I-SceI from the yeast Saccharomyce...

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Bibliographic Details
Published in:Acta Crystallogr F Struct Biol Commun
Main Authors: Prieto, Jesús, Redondo, Pilar, Merino, Nekane, Villate, Maider, Montoya, Guillermo, Blanco, Francisco J., Molina, Rafael
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2016
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909248/
https://ncbi.nlm.nih.gov/pubmed/27303901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X16007512
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