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Inhibition of prostaglandin E(2) receptor EP3 mitigates thrombin-induced brain injury

Prostaglandin E(2) EP3 receptor is the only prostaglandin E(2) receptor that couples to multiple G-proteins, but its role in thrombin-induced brain injury is unclear. In the present study, we exposed mouse hippocampal slice cultures to thrombin in vitro and injected mice with intrastriatal thrombin...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Han, Xiaoning, Lan, Xi, Li, Qiang, Gao, Yufeng, Zhu, Wei, Cheng, Tian, Maruyama, Takayuki, Wang, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908617/
https://ncbi.nlm.nih.gov/pubmed/26661165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X15606462
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