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Topological constraints of structural elements in regulation of catalytic activity in HDV-like self-cleaving ribozymes

Self-cleaving ribozymes fold into intricate structures, which orient active site groups into catalytically competent conformations. Most ribozyme families have distinct catalytic cores stabilized by tertiary interactions between domains peripheral to those cores. We show that large hepatitis delta v...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Webb, Chiu-Ho T., Nguyen, Dang, Myszka, Marie, Lupták, Andrej
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908430/
https://ncbi.nlm.nih.gov/pubmed/27302490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28179
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