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Topological constraints of structural elements in regulation of catalytic activity in HDV-like self-cleaving ribozymes
Self-cleaving ribozymes fold into intricate structures, which orient active site groups into catalytically competent conformations. Most ribozyme families have distinct catalytic cores stabilized by tertiary interactions between domains peripheral to those cores. We show that large hepatitis delta v...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4908430/ https://ncbi.nlm.nih.gov/pubmed/27302490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28179 |
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