The Janus kinase inhibitor Ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model

A hallmark of persistent HIV-1 infection in the central nervous system is increased activation of mononuclear phagocytes and surrounding astrogliosis, conferring persistent HIV-induced inflammation. This inflammation is believed to result in neuronal dysfunction and the clinical manifestations of HI...

Full description

Saved in:
Bibliographic Details
Published in:Neurobiol Dis
Main Authors: Haile, Woldeab B., Gavegnano, Christina, Tao, Sijia, Jiang, Yong, Schinazi, Raymond F., Tyor, William R.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907871/
https://ncbi.nlm.nih.gov/pubmed/26851503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.02.007
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items