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The Janus kinase inhibitor Ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model
A hallmark of persistent HIV-1 infection in the central nervous system is increased activation of mononuclear phagocytes and surrounding astrogliosis, conferring persistent HIV-induced inflammation. This inflammation is believed to result in neuronal dysfunction and the clinical manifestations of HI...
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| Veröffentlicht in: | Neurobiol Dis |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4907871/ https://ncbi.nlm.nih.gov/pubmed/26851503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.02.007 |
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