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The Janus kinase inhibitor Ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model

A hallmark of persistent HIV-1 infection in the central nervous system is increased activation of mononuclear phagocytes and surrounding astrogliosis, conferring persistent HIV-induced inflammation. This inflammation is believed to result in neuronal dysfunction and the clinical manifestations of HI...

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Bibliografiske detaljer
Udgivet i:Neurobiol Dis
Main Authors: Haile, Woldeab B., Gavegnano, Christina, Tao, Sijia, Jiang, Yong, Schinazi, Raymond F., Tyor, William R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907871/
https://ncbi.nlm.nih.gov/pubmed/26851503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.02.007
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