Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro

BACKGROUND: Since HIV-associated neurocognitive disorders (HANDs) occur in up to half of HIV-positive individuals, even with combined antiretroviral therapy (cART), adjunctive therapies are needed. Chronic CNS inflammation contributes to HAND and HIV encephalitis (HIVE). Baricitinib is a JAK 1/2 inh...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Gavegnano, Christina, Haile, Woldeab B., Hurwitz, Selwyn, Tao, Sijia, Jiang, Yong, Schinazi, Raymond F., Tyor, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764124/
https://ncbi.nlm.nih.gov/pubmed/31561750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1565-6
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