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Epigenetically Mediated Spontaneous Reduction of NFAT1 Expression Causes Imbalanced Metabolic Activities of Articular Chondrocytes in Aged Mice

OBJECTIVE: Abnormal metabolic activities of chondrocytes may cause articular cartilage (AC) degradation, but key transcription factors regulating metabolic activities in AC of aging individuals remain unknown. This study aimed to investigate the role of transcription factor NFAT1 in regulating the e...

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Publicado en:Osteoarthritis Cartilage
Autores principales: Zhang, Mingcai, Lu, Qinghua, Egan, Brian, Zhong, Xiao-bo, Brandt, Kenneth, Wang, Jinxi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907852/
https://ncbi.nlm.nih.gov/pubmed/26903200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2016.02.003
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