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ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y(1) Purinergic Receptor via a YPX(3)L Motif

Endocytic sorting and lysosomal degradation are integral to the regulation of G protein-coupled receptor (GPCR) function. Upon ligand binding, classical GPCRs are activated, internalized and recycled or sorted to lysosomes for degradation, a process that requires receptor ubiquitination. However, re...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Dores, Michael R., Grimsey, Neil J., Mendez, Francisco, Trejo, JoAnn
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907476/
https://ncbi.nlm.nih.gov/pubmed/27301021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157587
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