ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

The sorting of signaling receptors to lysosomes is an essential regulatory process in mammalian cells. During degradation, receptors are modified with ubiquitin and sorted by endosomal sorting complex required for transport (ESCRT)–0, –I, –II, and –III complexes into intraluminal vesicles (ILVs) of...

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Autori principali: Dores, Michael R., Chen, Buxin, Lin, Huilan, Soh, Unice J.K., Paing, May M., Montagne, William A., Meerloo, Timo, Trejo, JoAnn
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2012
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341166/
https://ncbi.nlm.nih.gov/pubmed/22547407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201110031
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