ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

The sorting of signaling receptors to lysosomes is an essential regulatory process in mammalian cells. During degradation, receptors are modified with ubiquitin and sorted by endosomal sorting complex required for transport (ESCRT)–0, –I, –II, and –III complexes into intraluminal vesicles (ILVs) of...

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Autores principales: Dores, Michael R., Chen, Buxin, Lin, Huilan, Soh, Unice J.K., Paing, May M., Montagne, William A., Meerloo, Timo, Trejo, JoAnn
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2012
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341166/
https://ncbi.nlm.nih.gov/pubmed/22547407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201110031
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