Characterization of SEMA3A-Encoded Semaphorin as a Naturally Occurring K(v)4.3 Protein Inhibitor and its Contribution to Brugada Syndrome

RATIONAL: SEMA3A-encoded semaphorin is a chemorepellent that disrupts neural patterning in the nervous and cardiac systems. In addition, SEMA3A has an amino acid motif that is analogous to hanatoxin, an inhibitor of voltage-gated K(+) channels. SEMA3A knockout mice exhibit an abnormal ECG pattern an...

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Publicado no:Circ Res
Main Authors: Boczek, Nicole J., Ye, Dan, Johnson, Eric K., Wang, Wei, Crotti, Lia, Tester, David J., Dagradi, Federica, Mizusawa, Yuka, Torchio, Margherita, Alders, Marielle, Giudicessi, John R., Wilde, Arthur A., Schwartz, Peter J., Nerbonne, Jeanne M., Ackerman, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907370/
https://ncbi.nlm.nih.gov/pubmed/24963029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.303657
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