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Characterization of SEMA3A-Encoded Semaphorin as a Naturally Occurring K(v)4.3 Protein Inhibitor and its Contribution to Brugada Syndrome
RATIONAL: SEMA3A-encoded semaphorin is a chemorepellent that disrupts neural patterning in the nervous and cardiac systems. In addition, SEMA3A has an amino acid motif that is analogous to hanatoxin, an inhibitor of voltage-gated K(+) channels. SEMA3A knockout mice exhibit an abnormal ECG pattern an...
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| Опубликовано в: : | Circ Res |
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| Главные авторы: | , , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4907370/ https://ncbi.nlm.nih.gov/pubmed/24963029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.303657 |
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