Transient Outward Current (I(to)) Gain-of-Function Mutations in the KCND3-Encoded Kv4.3 Potassium Channel and Brugada Syndrome

BACKGROUND: Brugada syndrome (BrS) is a sudden death predisposing genetic condition characterized electrocardiographically by ST-segment elevation in the leads V(1)-V(3). Given the prominent role of the transient outward current (I(to)) in BrS pathogenesis, we hypothesized that rare gain-of-function...

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Detalhes bibliográficos
Main Authors: Giudicessi, John R., Ye, Dan, Tester, David J., Crotti, Lia, Mugione, Alessandra, Nesterenko, Vladislav V., Albertson, Richard M., Antzelevitch, Charles, Schwartz, Peter J., Ackerman, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150551/
https://ncbi.nlm.nih.gov/pubmed/21349352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2011.02.021
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