Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation

Insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R) signaling plays an important role in tumor progression in patients with certain gastrointestinal tract cancers. In addition to lowering cholesterol in serum, statins have pleiotropic effects, including anti-oxidative, anti-inflammatory...

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Detalhes bibliográficos
Publicado no:Oncol Lett
Main Authors: JANG, HYUN JOO, HONG, EUN MI, PARK, SE WOO, BYUN, HYUN WOO, KOH, DONG HEE, CHOI, MIN HO, KAE, SEA HYUB, LEE, JIN
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906996/
https://ncbi.nlm.nih.gov/pubmed/27347133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2016.4569
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