Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer

Statin has been known not only as their cholesterol-lowering action but also on their pleiotropic effects including anti-inflammatory and anti-oxidant as well as anti-cancer effect. Nrf2 (NF-E2-related factor 2) is a transcription factor to activate cellular antioxidant response to oxidative stress....

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Jang, Hyun Joo, Hong, Eun Mi, Kim, Mikang, Kim, Jae Hyun, Jang, Juah, Park, Se Woo, Byun, Hyun Wu, Koh, Dong Hee, Choi, Min Ho, Kae, Sea Hyub, Lee, Jin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216792/
https://ncbi.nlm.nih.gov/pubmed/27323826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10078
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