Synergistic Effects of Simvastatin and Irinotecan against Colon Cancer Cells with or without Irinotecan Resistance

Aims. We here investigated whether the combination of simvastatin and irinotecan could induce the synergistic effect on colon cancer cells with or without resistance to irinotecan. Methods. We investigated cell proliferation assay and assessed cell death detection ELISA and caspase-3 activity assay...

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Detalhes bibliográficos
Publicado no:Gastroenterol Res Pract
Main Authors: Jang, Hyun Joo, Hong, Eun Mi, Jang, Juah, Choi, Jung Eun, Park, Se Woo, Byun, Hyun Woo, Koh, Dong Hee, Choi, Min Ho, Kae, Sea Hyub, Lee, Jin
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757714/
https://ncbi.nlm.nih.gov/pubmed/26966430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/7891374
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