Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes

We examined the effect of rapamycin on the life span of a mouse model of type 2 diabetes, db/db mice. At 4 months of age, male and female C57BLKSJ-lepr (db/db) mice (db/db) were placed on either a control diet, lacking rapamycin or a diet containing rapamycin and maintained on these diets over their...

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Bibliographic Details
Published in:J Gerontol A Biol Sci Med Sci
Main Authors: Sataranatarajan, Kavithalakshmi, Ikeno, Yuji, Bokov, Alex, Feliers, Denis, Yalamanchili, Himabindu, Lee, Hak Joo, Mariappan, Meenalakshmi M., Tabatabai-Mir, Hooman, Diaz, Vivian, Prasad, Sanjay, Javors, Martin A., Ghosh Choudhury, Goutam, Hubbard, Gene B., Barnes, Jeffrey L., Richardson, Arlan, Kasinath, Balakuntalam S.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906320/
https://ncbi.nlm.nih.gov/pubmed/26442901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glv170
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