Direct interaction of beta-amyloid with Na,K-ATPase as a putative regulator of the enzyme function

By maintaining the Na(+) and K(+) transmembrane gradient mammalian Na,K-ATPase acts as a key regulator of neuronal electrotonic properties. Na,K-ATPase has an important role in synaptic transmission and memory formation. Accumulation of beta-amyloid (Aβ) at the early stages of Alzheimer’s disease is...

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Pubblicato in:Sci Rep
Autori principali: Petrushanko, Irina Yu., Mitkevich, Vladimir A., Anashkina, Anastasia A., Adzhubei, Alexei A., Burnysheva, Ksenia M., Lakunina, Valentina A., Kamanina, Yulia V., Dergousova, Elena A., Lopina, Olga D., Ogunshola, Omolara O., Bogdanova, Anna Yu., Makarov, Alexander A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906314/
https://ncbi.nlm.nih.gov/pubmed/27296892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27738
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