Direct interaction of beta-amyloid with Na,K-ATPase as a putative regulator of the enzyme function

By maintaining the Na(+) and K(+) transmembrane gradient mammalian Na,K-ATPase acts as a key regulator of neuronal electrotonic properties. Na,K-ATPase has an important role in synaptic transmission and memory formation. Accumulation of beta-amyloid (Aβ) at the early stages of Alzheimer’s disease is...

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Publicado no:Sci Rep
Main Authors: Petrushanko, Irina Yu., Mitkevich, Vladimir A., Anashkina, Anastasia A., Adzhubei, Alexei A., Burnysheva, Ksenia M., Lakunina, Valentina A., Kamanina, Yulia V., Dergousova, Elena A., Lopina, Olga D., Ogunshola, Omolara O., Bogdanova, Anna Yu., Makarov, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906314/
https://ncbi.nlm.nih.gov/pubmed/27296892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27738
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