Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2

The 1,2,4-benzothiadiazine 1,1-dioxide type of positive allosteric modulators of the ionotropic glutamate receptor A2 (GluA2) are promising lead compounds for the treatment of cognitive disorders, e.g., Alzheimer’s disease. The modulators bind in a cleft formed by the interface of two neighboring li...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Krintel, Christian, Francotte, Pierre, Pickering, Darryl S., Juknaitė, Lina, Pøhlsgaard, Jacob, Olsen, Lars, Frydenvang, Karla, Goffin, Eric, Pirotte, Bernard, Kastrup, Jette S.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2016
Fag:
Channels and Transporters
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906162/
https://ncbi.nlm.nih.gov/pubmed/27276258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.04.032
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