Oxidation of RyR2 Has a Biphasic Effect on the Threshold for Store Overload-Induced Calcium Release

At the single-channel level, oxidation of the cardiac ryanodine receptor (RyR2) is known to activate and inhibit the channel depending on the level of oxidation. However, the mechanisms through which these changes alter the activity of RyR2 in a cellular setting are poorly understood. In this study,...

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Bibliographic Details
Published in:Biophys J
Main Authors: Waddell, Helen M.M., Zhang, Joe Z., Hoeksema, Katie J., McLachlan, Julia J., McLay, Janet C., Jones, Peter P.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2016
Subjects:
Channels and Transporters
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906161/
https://ncbi.nlm.nih.gov/pubmed/27276257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.04.036
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