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POT1-TPP1 binding and unfolding of telomere DNA discriminates against structural polymorphism

Telomeres are nucleoprotein complexes that reside at the ends of linear chromosomes and help maintain genomic integrity. POT1 and TPP1 are telomere-specific proteins that bind as a heterodimer to single-stranded telomere DNA to prevent illicit DNA damage responses and to enhance telomerase-mediated...

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Foilsithe in:J Mol Biol
Main Authors: Mullins, Michael R., Rajavel, Malligarjunan, Hernandez-Sanchez, Wilnelly, de la Fuente, Maria, Biendarra, Sherri M., Harris, Michael E., Taylor, Derek J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905795/
https://ncbi.nlm.nih.gov/pubmed/27173378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.04.031
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